GENERAL CATALOGUE
MAGL-IN-12
HY-116143 · 50 mg
MedChemExpress · Cat: HY-116143
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Manufacturer product page
medchemexpress.com/magl-in-12.htmlCatalog No: HY-116143
CAS No: 1352011-38-1
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
SAR127303 is an orally active, selective, competitive monoacylglycerol lipase MAGL covalent inhibitor with IC50s of 3.8 nM and 29 nM for mouse and human MAGL, respectively. SAR127303 potently elevates hippocampal levels of 2-AG in mice. SAR127303 decreased long term potentiation LTP of CA1 synaptic transmission and acetylcholine release in the hippocampus. SAR127303 produces antinociceptive effects in assays of inflammatory and visceral pain. SAR127303 slows down epileptogenesis.
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