MAO A/HSP90-IN-1

Description

MAO A/HSP90-IN-1 4-b is a MAO A/HSP90 dual inhibitor with IC50 value of 1.77 ?M and 0.019 ?M in Glioblastoma GBM GL26 cells and HSP90?, respectively. MAO A/HSP90-IN-1 4-b can inhibit MAO A activity, HSP90 binding and the expression of HER2 and phospho-Akt to inhibit the growth of GBM, they also reduce PD-L1 expression, which inhibits T cell activation. MAO A/HSP90-IN-1 4-b have potential to inhibit tumor immune escape. MAO A/HSP90-IN-1 4-b can be used for brain tumor-related diseases research.