MAO-B-IN-45

Description

MAO-B-IN-45 is a dual inhibitor of ferroptosis and MAO-B. MAO-B-IN-45 shows selectivity towards MAO-B with an IC50 of 87.47 nM and selectivity exceeding 229-fold for MAO-B over MAO-A. MAO-B-IN-45 has excellent antiferroptosis activity through modulation of the iron metabolic pathway and GSH-GPX4 axis in vitro. MAO-B-IN-45 improves cognitive and behavioral impairments in 3AAAasAaTg APP/Tau/Ps1 AD mouse and significantly reduced the levels of ferritin heavy chain 1 FTH1 , APP, and Tau phosphorylation p-Tau proteins in the brain.