MAO-B-IN-46

Description

MAO-B-IN-46 Compound 16 is a selective hMAO-B inhibitor IC50: 26.8 nM , with weak activity against hMAO-A IC50: 7.2054 ?M . MAO-B-IN-46 Compound 8 also acts as an ?-amylase inhibitor IC50: 19.46 ?M . MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 ?M and 17.71 ?M, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinsons disease, diabetes, and diseases related to oxidative stress resistance.