MAP2K2 Mouse Monoclonal Antibody

Description

EnkiLife offers the MAP2K2 Mouse Monoclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,ICC,ELISA,FC application. Alternative Names of Immunogen: MEK2; MKK2; MAPKK2. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,ICC 1:200-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400 Background: MAP2K2, also called MEK2, it is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. Research Area: TGF-beta signaling pathway,PI3K-Akt signaling pathway,MAPK signaling pathway,Jak-STAT signaling pathway