GENERAL CATALOGUE
Marcfortine A
HY-126638 · 1 mg
MedChemExpress · Cat: HY-126638
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Catalog No: HY-126638
CAS No: 75731-43-0
Category: Anti-infection
Pack Size: 1 mg
Brand: MedChemExpress
Description
Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus LD99=0.06 ?g/mL and inhibits motility of adult worms EC50=2 ?M . Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds ED95s=0.33, 0.11, and 2.5 mg/animal, respectively . It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing ?3 subunit-containing human nicotinic acetylcholine receptors nAChRs and muscle-type nAChRs, respectively.
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