GENERAL CATALOGUE
Marein
HY-N7676 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-N7676
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Catalog No: HY-N7676
CAS No: 535-96-6
Category: Cell Cycle DNA Damage
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3? to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC50 of 100 ?M. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects.