MASTL/Aurora A-IN-1

Description

MASTL/Aurora A-IN-1 Compound MA4 is a dual inhibitor of MASTL and Aurora A kinases with IC50 values of 0.56 ?M and 0.16 ?M, respectively. MASTL/Aurora A-IN-1 has broad-spectrum anticancer activity and has potent anticancer activity against SR leukemia , K-562 leukemia , MDA-MB-435 melanoma , MOLT-4 leukemia , and SK-MEL-2 melanoma cell lines in NCI-60 cancer cell lines with GI50 values of 0.023, 0.032, 0.037, 0.044, and 0.051 ?M, respectively. MASTL/Aurora A-IN-1 inhibits Aurora A and MASTL kinases, inducing cell cycle G2/M arrest, thereby inhibiting cancer cell proliferation. MASTL/Aurora A-IN-1 can be used in cancer research, especially for tumors with dysregulated mitosis.