GENERAL CATALOGUE
MC-25B
HY-170983 · 50 mg
MedChemExpress · Cat: HY-170983
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Catalog No: HY-170983
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
MC-25B is a specific FKBP12 PROTAC degrader. MC-25B degrades FKBP12 with a DC50 of 0.35 ?M and a Dmax of 89 %. MC-25B facilitates the degradation of nuclear-localized FKBP12 through a DCAF16-dependent mechanism. Pink: FKBP12 ligand HY-170988 ; Blue: E3 ligase ligand HY-170986 ; Black: linker HY-128844 ; FKBP12 ligand+ linker HY-170987 .
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