GENERAL CATALOGUE
MCB-22-174
HY-165607S · 1 mg
MedChemExpress · Cat: HY-165607S
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medchemexpress.com/mcb-22-174.htmlCatalog No: HY-165607S
CAS No: 3058199-58-6
Category: MAPK ERK Pathway
Pack Size: 1 mg
Brand: MedChemExpress
Description
MCB-22-174 is a deuterated Piezo1 agonist, with an EC50 value of 6.28 ?M. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca2+ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers Comp, Acan and adipogenesis markers Lpl, Fabp4 in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading HU model rats. MCB-22-174 can be used for the study of disuse osteoporosis OP .
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