GENERAL CATALOGUE
MCB-36
HY-176786 · 5 mg
MedChemExpress · Cat: HY-176786
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Catalog No: HY-176786
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
MCB-36 is a VHL-recruiting pan-KRAS PROTAC degrader without affecting KRAS transcription. MCB-36 exhibits minimal effects on HRAS and NRAS protein levels. MCB-36 binds to the GDP-loaded state of G12D, G12C, G12V, and wild-type KRAS with high affinities Kd ? 1 pM. MCB-36 decreases p-ERK levels, leading to cell apoptosis. MCB-36 effectively suppress KRASG12C inhibitor-resistant cancer cells and remodel the tumor immune microenvironment. MCB-36 can be used for the study of colorectal cancer and lung cancer Pink: Target protein ligand; Blue: E3 ligand HY-112078 ; Black: Linker HY-W091879 .
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