McN-A-343

Description

McN-A-343 is a selective M1 muscarinic agonist that stimulates muscarinic transmission in sympathetic ganglia. McN-A-343 produces a significant inhibitory effect on Muscarine HY-121404 -evoked catecholamine secretion from the isolated perfused rat adrenal gland. McN-A-343 is involved in the regulation of neuronal firing and activates enteroendocrine L cells to release glucagon-like peptide 1 GLP-1 and modulates the secretion of ?-melanocyte stimulating hormone ?-MSH from the pituitary gland in the central nervous system. McN-A-343 reduces colonic inflammation and oxidative stress in Acetic acid HY-Y0319 -induced ulcerative colitis UC mice. McN-A-343 can be used for the study of ulcerative colitis.