GENERAL CATALOGUE
MD-4251
HY-174458 · 50 mg
MedChemExpress · Cat: HY-174458
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Manufacturer product page
medchemexpress.com/md-4251.htmlCatalog No: HY-174458
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
MD-4251 is an orally active MDM2 PROTAC degrader. MD-4251 potently degrades MDM2 in RS4;11 cells DC50: 0.2 nM and actives p53. MD-4251 shows strong antiproliferative activity against acute leukemia cells wild-type p53 with minimal efficacy in mutant type. MD-4251 induces complete tumor regression in RS4;11 xenograft mice model. Pink: MDM2 ligand HY-130684 ; Blue: CRBN ligase ligand HY-W883326 ; Black: linker
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