MDM2 Mouse Monoclonal Antibody

Description

EnkiLife offers the MDM2 Mouse Monoclonal Antibody. This antibody reacts with Human species and is suitable for IHC,ELISA,FC application. Alternative Names of Immunogen: HDMX; LSKB; hdm2; ACTFS. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:200-1:1000,ELISA 1:5000-1:20000,FC 1:200-1:400 Background: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. Research Area: Apoptosis,PI3K-Akt signaling pathway