GENERAL CATALOGUE
ME3221
HY-121550 · 1 mg
MedChemExpress · Cat: HY-121550
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Catalog No: HY-121550
CAS No: 139958-16-0
Category: Metabolic Enzyme Protease
Pack Size: 1 mg
Brand: MedChemExpress
Description
ME3221 is an angiotensin AT1 receptor antagonist that effectively antagonizes the pressor response to angiotensin II in rats and marmosets without affecting the hypotensive response to bradykinin. It demonstrates potent antihypertensive effects in renal hypertensive rats and spontaneously hypertensive rats SHR , with efficacy comparable to or better than losartan in vivo. ME3221s repeated administration in SHR results in sustained and stable hypotensive effects without affecting heart rate, indicating its potential for treating both renal and essential hypertension similarly to losartan.
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