GENERAL CATALOGUE
Melagatran
HY-129056 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-129056
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Catalog No: HY-129056
CAS No: 159776-70-2
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Melagatran is a reversible, selective, orally active direct inhibitor of thrombin with a Ki of 2 nM. Melagatran binds directly to the active site of thrombin, inhibiting thrombin-mediated conversion of fibrinogen to fibrin. Melagatran reduces the DNA binding activity of NF-?B and AP-1. Melagatran reduces fibrin deposition in organs, alleviates ischemic brain damage, and reduces the size of advanced atherosclerotic lesions. Melagatran can be used in the study of cardiovascular disease coronary thrombosis, atherosclerosis and ischemic brain damage.
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