GENERAL CATALOGUE
Melatonin-Tamoxifen Conjugate
HY-169382 · 50 mg
MedChemExpress · Cat: HY-169382
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Manufacturer product page
medchemexpress.com/melatonin-tamoxifen-conjugate.htmlCatalog No: HY-169382
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
Melatonin-Tamoxifen Conjugate compound 16c is an anticancer drug conjugate composed of Melatonin HY-B0075 and Tamoxifen HY-13757A , which is a potent antagonist of ER? IC50=863 nM . Melatonin-Tamoxifen Conjugate binds to MLT receptor Ki=3.1 nM and promotes ?-arrestin EC50=914 nM and ERK activation EC50=98 nM in cells expressing hMT1 receptor. Melatonin-Tamoxifen Conjugate against several common cell lines MCF-7, MDA-MB-231, and HT-1080 with IC50s of 6.8 ?M, 6.4 ?M, and 1.7 ?M, respectively.
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