Melicopine

Description

Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC50 values of 29.7 and 33.7 AAasAasAAmug/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP IC50 values of 47.9 and 37.8 AAasAasAAmug/mL , but has no effect on non-cancerous HEK293 cells IC50 greater than 100 AAasAasAAmug/mL . Melicopine holds promise for research in anticancer and anti-infection fields.