MET Mouse Monoclonal Antibody

Description

EnkiLife offers the MET Mouse Monoclonal Antibody. This antibody reacts with Human species and is suitable for ICC,ELISA,FC application. Alternative Names of Immunogen: HGFR; AUTS9; RCCP2; c-Met; DFNB97. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: ICC 1:100-1:500,ELISA 1:5000-1:20000,FC 1:200-1:400 Background: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. Research Area: TGF-beta signaling pathway,PI3K-Akt signaling pathway,Hippo signaling pathway