Methyl-L-NIO hydrochloride

Description

Methyl-L-NIO compound 2d hydrochloride is a potential selective inhibitor IC50: 70 ?M of dimethylarginine dimethylaminohydrolase hDDAH. Methyl-L-NIO also has inhibitory activity against NO synthase. The inhibition rates of Methyl-L-NIO on different isoforms of NO synthase at a concentration of 100 ?M are 77 % nNOS , 20 % eNOS , and 72 % iNOS respectively; the inhibition rates at a concentration of 1 mM are 100 % nNOS , 85 % eNOS , 100 % iNOS .