Methylhydroquinone

Description

Methylhydroquinone is an orally active COX inhibitor with IC50s of 480.7 ?M and 52.2 ?M for ovine COX-1 and human recombinant COX-2, respectively. Methylhydroquinone has potential DNA damaging effects: 1 inhibiting COX-1 to reduce prostaglandin synthesis and exert anti-inflammatory activity; 2 inducing DNA single-strand breaks. Methylhydroquinone exerts its effects by competitively binding to the active sites of COX-1 such as Tyr385, Met522 and non-covalent interactions.