Metopimazine-d6

Description

Metopimazine-d6 EXP999-d6; RP9965-d6 is the deuterium labeled Metopimazine HY-116578 . Metopimazine EXP999; RP9965 is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks.