GENERAL CATALOGUE
MG 149
HY-15887 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-15887
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Catalog No: HY-15887
CAS No: 1243583-85-8
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
MG149 Tip60 HAT inhibitor is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF IC50 = 47 uM ; little potent for PCAF and p300 IC50 200 uM. MG 149 inhibits KAT8 and blocks PINK1 kinase activity. MG 149 can induce mitochondrial depolarization and promote PINK1 dependent mitochondrial clearance. MG 149 can reverse chronic restraint stress CRS induced hypertension and related molecular changes. MG 149 commonly used in research on diseases such as hypertension and Parkinsons disease.
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