MGTA-117 Antibody

Description

MGTA-117 is a humanized monoclonal antibody targeting CD117. MGTA-117 can be used for synthesis of antibody-drug conjugate ADC , utilizing an amanitin payload. MGTA-117 has potent anti-tumor activity and increases survival in three acute myeloid leukemia AML xenograft hNSG mice models Kasumi-1, AML PDX 1 and AML PDX 2 . MGTA-117 enables hematopoietic stem cell transplantation HSCT preprocessing in AML, myelodysplasia with excess blasts MDS-EB and gene therapy.