GENERAL CATALOGUE
MI-2-2
HY-108350 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-108350
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Catalog No: HY-108350
CAS No: 1454920-20-7
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
MI-2-2 is a potent menin-MLL inhibitor. MI-2-2 binds to menin with low nanomolar affinity Kd=22nM and very effectively disrupts the bivalent protein-protein interaction between menin and MLL. MI-2-2 has specific and very pronounced activity in MLL leukemia cells, including inhibition of cell proliferation, down-regulation of Hoxa9 expression, and differentiation.
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