GENERAL CATALOGUE
MI-3454
HY-136360 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-136360
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Manufacturer product page
medchemexpress.com/mi-3454.htmlCatalog No: HY-136360
CAS No: 2134169-43-8
Category: Epigenetics
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
MI-3454 is an orally active, highly potent and selective menin-MLL1 interaction inhibitor with an IC50 of 0.51 nM. MI-3454 inhibits proliferation, induces differentiation and complete remission or regression of leukemia in mouse models of MLL1-rearranged or NPM1-mutated leukemia through downregulation of key genes involved in leukemogenesis.
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