GENERAL CATALOGUE
MI-883
HY-173033 · 50 mg
MedChemExpress · Cat: HY-173033
Reach 3+ verified distributors
Manufacturer product page
medchemexpress.com/mi-883.html
Sponsored
Catalog No: HY-173033
CAS No: 2530027-71-3
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
MI-883 is the orally active agonist for Constitutive Androstane Receptor CAR, EC50=73 nM and the antagonist for Pregnane X Receptor PXR, IC50=0.1 ?M . MI-883 stimulates CAR LBD assembly EC50=0.38 AAasAasAAmuM and CAR3 variant activation EC50=0.074 AAasAasAAmuM , induces CYP2B6 mRNA expression in HepaRG and primary human hepatocytes. MI-883 inhibits basal PXR activity IC50=2.03 AAasAasAAmuM in transiently transfected HepG2 cells, blocks CYP3A4 mRNA expression in HepG2. MI-883 regulates cholesterol metabolism and bile acid excretion, improves hypercholesterolemia in mouse models.
More from MedChemExpress
(R)-Trolox (Standard)
HY-101445AR
Metabolic Enzyme Protease
Propentofylline-d6
HY-107203S
Metabolic Enzyme Protease
PTP1B-IN-2
HY-100462
Metabolic Enzyme Protease
Stearic acid-PEG-Mal, MW 2000
HY-W440950
Metabolic Enzyme Protease
Enazadrem phosphate
HY-U00024A
Metabolic Enzyme Protease
1,2-Dihexanoyl-sn-glycero-3-phosphocholine
HY-W127457
Metabolic Enzyme Protease
(R)-KT109
HY-126031
Metabolic Enzyme Protease
?-Glucosidase-IN-31
HY-149409
Metabolic Enzyme Protease