GENERAL CATALOGUE
MI1013
HY-175266 · 50 mg
MedChemExpress · Cat: HY-175266
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Catalog No: HY-175266
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
MI1013 is a PROTAC PXR degrader DC50 = 89 nM, Dmax = 82 % . MI1013 degrades PXR in human hepatocellular carcinoma RG cells HepaRG . MI1013 specifically and safely regulates CYP3A4 promoter activity through PXR degradation. MI1013 affects several key genes involved in sulfate conjugation e.g., SULT1E1 , bile acid synthesis CYP7A1 , gluconeogenesis PCK1 , ketone synthesis HMGCS20 , and hepatocyte proliferation MKI67 . Pink: PXR ligand 3: HY-175267, Blue: Pomalidomide-propargyl ligand: HY-W410002, Pink + Black: PXR ligand-Linker Conjugate 1: HY-175268 .
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