MIB2 Rabbit Polyclonal Antibody

Description

EnkiLife offers the MIB2 Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,ELISA application. Alternative Names of Immunogen: MIB2 SKD ZZANK1. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,ELISA 1:5000-1:20000 Background: function:E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene. pathway:Protein modification; protein ubiquitination. PTM:Ubiquitinated. Possibly via autoubiquitination. similarity:Contains 1 ZZ-type zinc finger. similarity:Contains 2 MIB/HERC2 domains. similarity:Contains 2 RING-type zinc fingers. similarity:Contains 9 ANK repeats. subcellular location:Colocalizes with endosomal compartments. subunit:Interacts with actin monomer. tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.