GENERAL CATALOGUE
mIDH1-IN-1
HY-143234 · 50 mg
MedChemExpress · Cat: HY-143234
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Manufacturer product page
medchemexpress.com/midh1-in-1.htmlCatalog No: HY-143234
CAS No: 2757155-96-5
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
mIDH1-IN-1 compound 43 is a potent and selective mIDH1 mutant isocitrate dehydrogenases 1 inhibitor, with an IC50 of 961.5 nM. mIDH1-IN-1 potently inhibits intracellular 2-HG 2-hydroxyglutarate production in HT1080 cells, with an EC50 of 208.6 AAasAasAA+/- 8.0 nM. mIDH1-IN-1 shows a significant anti-proliferation activity on IDH1 mutant-U-87 cells, with an IC50 of 41.8 nM. mIDH1-IN-1 is an antitumor agent, and can be used for IDH1 mutated solid tumors research.
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