Milameline

Description

Milameline CI-979; RU35926 is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 AAasAasAAmuM for M1-, 1.1 AAasAasAAmuM for M2-, 1.5 AAasAasAAmuM for M3-, and 1.9 AAasAasAAmuM for M4-muscarinic receptors. Milameline has a higher affinity for sites 3H CMD IC50 = 20 nM , than 3H QNB, IC50 = 3059 nM . Milameline produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine HY-N0296 . Milameline can be used for the study of AlzheimerAAasAasAas Disease.