Milbemycin A4 oxime

Description

Milbemycin A4 oxime 5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime is a derivative of Milbemycin A4 HY-126906 and a component of Milbemycin oxime HY-B0778 , both of which have insecticidal and nematicidal activities. Milbemycin A4 oxime 0.05 mg/kg reduces the number of microfilariae in naturally infected dogs with D. immitis and inhibits the growth of clinical isolates of Candida glabrata MIC80=16-32 ?g/mL . Milbemycin A4 oxime 2.5 ?g/mL blocks the efflux of Fluconazole HY-B0101 from clinical isolates of Candida glabrata. Milbemycin A4 oxime enhances doxorubicin-induced cell growth inhibition and increases the intracellular accumulation of doxorubicin and P-glycoprotein substrate Rhodamine 123 HY-D0816 in doxorubicin-resistant but not sensitive MCF-7 breast cancer cells in a concentration-dependent manner.