Mitotane-13C12

Description

Mitotane-13C12 2,4?-DDD-13C12 is 13C labeled Mitotane. Mitotane 2,4?-DDD , an isomer of DDD and derivative of dichlorodiphenyltrichloroethane DDT , is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol FC accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor SXR activation, and has agent-agent interactions.