GENERAL CATALOGUE
MK-8825
HY-117694 · 50 mg
MedChemExpress · Cat: HY-117694
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medchemexpress.com/mk-8825.htmlCatalog No: HY-117694
CAS No: 1380887-60-4
Category: GPCR G Protein
Pack Size: 50 mg
Brand: MedChemExpress
Description
MK-8825 is an orally active, potent and selective CGRP receptor antagonist, which shows concentration-dependent inhibition of Capsaicin HY-10448 -evoked dermal blood flow with an EC50 value of about 7.4 ?M. MK-8825 inhibits CGRP-induced spontaneous nociceptive facial grooming behaviors, neuronal activation in the trigeminal nucleus, and systemic release of pro-inflammatory cytokines in a mouse model of acute orofacial masseteric muscle pain. MK-8825 is promising for research of acute migraine.
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