GENERAL CATALOGUE
MKC8866
HY-104040 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-104040
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medchemexpress.com/IRE-1_alpha__inhibitor_1.html
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Catalog No: HY-104040
CAS No: 1338934-59-0
Category: Cell Cycle DNA Damage
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
MKC8866, a salicylaldehyde analog, is a potent, selective IRE1 RNase inhibitor with an IC50 of 0.29 AZA14M in human vitro. MKC8866 strongly inhibits Dithiothreitol-induced X-box-binding protein 1-spliced XBP1s expression with an EC50 of 0.52 AZA14M and unstresses RPMI 8226 cells with an IC50 of 0.14 AZA14M. MKC8866 inhibits IRE1 RNase in breast cancer cells leading to the decreased production of pro-tumorigenic factors and it can inhibits prostate cancer PCa tumor growth.
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