ML 2-14

Description

ML 2-14 is a PROTAC targeting BRD4 with a C4 alkyl linker. ML 2-14 consists of the E3 ligase ligand EN219 HY-115715 bule part , the target protein ligand JQ-1 HY-13030 red part , and the PROTAC linker balck part . ML 2-14 can effectively degrade BRD4 in 231MFP breast cancer cells, and this effect can be reversed by the proteasome inhibitor Bortezomib HY-10227 and the E1 activase inhibitor TAK-243 HY-100487 .