ML-20

Description

ML-20, Malabaricone C HY-N8518 analogue, is a autophagy inhibitor and radiosensitizer. ML-20 inhibits cell growth, induces cell apoptosis . ML-20 induces DNA double-strand breaks, loss of mitochondrial membrane potential MMP , and lysosomal membrane permeabilization LMP . ML-20 induces endoplasmic reticulum stress and concurrent inhibition of autophagy flux due to LMP .