ML-7

Description

ML-7 is a myosin light chain kinase inhibitor with the activity to inhibit superoxide anion O 2 - release in human neutrophils. ML-7 can affect the activity of neutrophils independently of myosin light chain kinase. ML-7 inhibits the extracellular O 2 - release of stimulated cells, but has no effect on the intracellular O 2 - production. ML-7 also strongly inhibits the binding of the intracellular compartment of oxide production to the cell membrane, indicating that it plays a key role in stimulated neutrophils. At the same time, ML-7 protects cardiac function from ischemia/reperfusion injury.