GENERAL CATALOGUE
ML-SI3
HY-139426 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-139426
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medchemexpress.com/ml-si3.htmlCatalog No: HY-139426
CAS No: 891016-02-7
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
ML-SI3 is a mixture of cis/trans ML-SI3 HY-139426A , which is a TRPML1/2 channel inhibitor with IC50s of 4.7 ?M and 1.7 ?M, respectively. ML-SI3 also inhibits lysosomal calcium efflux and blocks downstream TRPML1-mediated autophagy. The cis/trans ML-SI3 HY-139426A components of ML-SI3 are TRPML2 activators with EC50s of 3.3 ?M and 9.4 ?M, respectively.
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