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ML350
GENERAL CATALOGUE

ML350

HY-116163 · 50 mg

MedChemExpress · Cat: HY-116163

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medchemexpress.com/ml350.html
Catalog No: HY-116163
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress

Description

ML350 CYM50202 is a highly potent OPRK1 antagonist with selectivity and broad biological applications. With IC50 values of 9-16 nM, ML350 shows high selectivity for OPRK1, with selectivity of 219-382-fold and 20-35-fold relative to OPRD1 and OPRM1, respectively. ML350 exhibited favorable characteristics in in vivo pharmacokinetic analysis, including high passive membrane permeability and moderate human plasma protein binding. Extensive screening of ML350 against multiple ion channels, receptors, and transporters showed that it does not have adverse off-target effects.

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