GENERAL CATALOGUE
ML417
HY-136390 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-136390
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Catalog No: HY-136390
CAS No: 1386162-69-1
Category: GPCR G Protein
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
ML417 is a selective and brain penetrant D3 dopamine receptor D3R agonist, with an EC50 of 38 nM. ML417 potently promotes D3R-mediated ?-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons.
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