MLK1/2 Rabbit Polyclonal Antibody

Description

EnkiLife offers the MLK1/2 Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse species and is suitable for IHC,ICC/IF,ELISA application. Alternative Names of Immunogen: MAP3K9; MLK1; PRKE1; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; MAP3K10; MLK2; MST; Mitogen-activated protein kinase kinase kinase 10; Mixed lineage kinase 2; Protein kinase MST. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:5000-1:10000 Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein. cofactor:Magnesium. enzyme regulation:Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation. function:Activates the JUN N-terminal pathway. PTM:Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-312 is likely to be the main autophosphorylation site. similarity:Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. similarity:Contains 1 protein kinase domain. similarity:Contains 1 SH3 domain. subunit:Homodimer. tissue specificity:Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin. Research Area:Regulation of Actin Dynamics; SAPK_JNK; Stem cell pathway; B_Cell_Antigen