Phospho-MLKL(S345) Rabbit Monoclonal Antibody

Description

EnkiLife offers the Phospho-MLKL(S345) Rabbit Monoclonal Antibody. This antibody reacts with Mouse species and is suitable for WB,IP application. Alternative Names of Immunogen: hMLKL ; Mixed lineage kinase domain like; Mixed lineage kinase domain like protein; Mixed lineage kinase domain like pseudokinase;;p-Mlkl (S345). The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:1000-1:2000,IP 1:20-1:50 Background: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process.Does not have protein kinase activity.Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage.