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MLN-4924, NEDD8-activating enzyme inhibitor
ab216470 · 200 µg
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Catalog No: ab216470
Category: Biochemicals
Pack Size: 200 µg
Brand: abcam
Description
MW 443.5 Da, Purity >98 %. Potent NEDD8-activating enzyme NAE inhibitor IC50 = 4.7 nM . Selective relative to the closely related activating enzymes ubiquitin-activating enzyme UAE and SUMO-activating enzyme SAE . Adenosine 5-monophosphate analog. Disrupts cullin-RING ligase CRL -mediated protein turnover leading to apoptosis in human tumour cells by deregulating S-phase DNA synthesis.
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