GENERAL CATALOGUE
MLS6357
HY-175504 · 50 mg
MedChemExpress · Cat: HY-175504
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Catalog No: HY-175504
CAS No: 932544-59-7
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
MLS6357 is a D3 dopamine receptor D3R -selective positive allosteric modulator PAM -antagonist. MLS6357 exhibits antagonist activity in the D3R-mediated and the BRET-based ?-arrestin recruitment assay with IC50s of 13 and 14 ?M, and no activity for other DAR subtypes D1R/D2R/D4R/D5R IC50 100 ?M. MLS6357 is also an antagonist in the D3R-mediated Go-BRET assay with an IC50 of 17 ?M. MLS6357 can be used for the study of neuropsychiatric disorders, including substance use disorder.
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