GENERAL CATALOGUE
MM-433593
HY-115004 · 1 mg
MedChemExpress · Cat: HY-115004
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Manufacturer product page
medchemexpress.com/mm-433593.htmlCatalog No: HY-115004
CAS No: 1006604-91-6
Category: Metabolic Enzyme Protease
Pack Size: 1 mg
Brand: MedChemExpress
Description
MM-433593 is a potent and selective inhibitor of fatty acid amide hydrolase-1 FAAH-1 that is orally administered to inhibit pain, inflammation, and related disorders. Pharmacokinetic studies of MM-433593 in macaques revealed a biphasic elimination profile with a rapid distribution phase and a slower elimination phase, with a systemic clearance of 8-11 mL/min/kg. MM-433593 exhibits moderate oral bioavailability 14-21 % and its metabolism primarily involves oxidation of the methyl group on the indole ring, resulting in a variety of sulfate, glucuronide, or glutathione-conjugated metabolites.
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