MMRi62

Description

MMRi62, a ferroptosis inducer targeting MDM2-MDM4 negative regulators of tumor suppressor p53 . MMRi62 shows a P53-independent pro-apoptotic activity against pancreatic ductal adenocarcinoma PDAC cells and induce autophagy. MMRi62 inducesferroptosis, resulting in a increase of reactive oxygen and lysosomal degradation of ferritin heavy chain FTH1 . MMRi62 also leads to proteasomal degradation of mutant p53, also inhibits orthotopic xenograft PDAC mouse model in vivo with high frequency mutation characteristics of KRAS and TP53.12.