Moexiprilat

Description

Moexiprilat is an inhibitor of angiotensin-converting enzyme ACE; IC50=2.1 nM and an active metabolite of the prodrug Moexipril HY-117281 . It is formed from moexipril in vivo by side chain ester hydrolysis. Moexiprilat 10 nM prevents the estrone- or angiotensin II-stimulated proliferation of primary neonatal rat cardiac fibroblasts. It reduces mean arterial blood pressure and increases the levels of atrial natriuretic peptide, a marker of hypertension, in ovariectomized mice when administered at a dose of 50 mg/kg per day.