Monotropein

Description

Monotropein is an iridoid glycoside that can be isolated from the roots of Morinda officinalis. Monotropein inhibits the expression of inflammatory mediators in dextran sulfate sodium DSS -induced colitis mouse model. Monotropein exerts protective effects against IL-1?-induced apoptosis and catabolic responses on osteoarthritis chondrocytes. Monotropein has cartilage protective activity. Monotropein can alleviate Cisplatin HY-17394 -induced acute kidney injury by inhibiting oxidative damage, inflammation and apoptosis through activation of Nrf2/HO-1 pathway and inhibition of NF-?B signaling. Monotropein can be studied in research for osteoarthritis, acute kidney injury and acute lung injury.