

HY-155830 · 5 mg
MedChemExpress · Cat: HY-155830
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medchemexpress.com/pde4-in-14.htmlDescription
Morcamilast ME3183 is a selective and orally active PDE4 inhibitor, with IC50s of 1.28 nM PDE4A1A , 2.33 nM PDE4B1 , and 1.63 nM PDE4D2 respectively. Morcamilast shows weak inhibition of PDEs other than PDE4s Morcamilast is an anti-inflammatory agent and inhibits LPS HY-D1056 -induced release of TNF-?, IL-12/23p40, IL-23, and IL-17A in human PBMCs and T cells. Morcamilast has antipruritic effect and can be used in the study of psoriasis, atopic dermatitis, and other inflammatory diseases.







